Exploring Artemisia Biennis Phytochemicals as Inhibitors of c-Met and Motor Proteins: A Computational Approach Toward Glioblastoma Therapy
Published: 2025
Author(s) Name: Somayeh Sabaghan, Pardeep Yadav and Saurabh Kumar Jha |
Author(s) Affiliation: Dept. of Biotechnology, School of Engg. and Tech., Sharda Univ., Greater Noida, Uttar Pradesh, India
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Abstract
Glioblastoma multiforme (GBM) presents as a fast-growing brain tumour resulting in poor clinical outcomes because it shows resistance to standard treatment modalities. GBM progression as well as therapeutic resistance results from both abnormal receptor tyrosine kinase activation such as c-Met and overexpressed mitotic motor proteins. In this study, using PyRx 0.8 with AutoDock Vina software to virtually screen 24 Artemisia biennis phytochemicals against c-Met (PDB ID: 5EYD) and a motor protein (PDB ID: 4JT5) was the approach. An accurate sampling approach was achieved through the defined docking grid parameters derived from validated binding sites of both proteins with an exhaustiveness value set at 8. The most effective compound IMPHY011581 showed strong dual-target potential through bindings of –7.7 kcal/mol and –7.0 kcal/mol to the proteins 4JT5 and 5EYD respectively. All ligands exhibited stable docking poses with RMSD values of 0.0 Å. These findings suggest that selected A. Biennis phytoconstituents may serve as promising multitarget inhibitors and provide a foundation for further development of natural therapeutic agents against glioblastoma.
Keywords: Artemisia biennis, c-Met, Glioblastoma, Molecular docking, Motor protein.
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