Recent Advances in Pyrazole Derivatives as Potential Antimicrobial Agents

Abstract

The antimicrobial drug resistant against various bacterial strains have become a challenging situation for health due to which many classical antibiotics become inactive nowadays. To overcome this challenge, various antimicrobial agents have been developed to treat the infectious diseases spread by bacteria over the last decades. In the ongoing battle against bacterial infections, the need for new and effective antibacterial agents is paramount. Heterocyclic compounds regarded for drug discovery due to their drug like properties and structural characteristics. Pyrazole, a five-membered heterocyclic compound, has garnered significant attention in recent years due to its potential as an antibacterial agent. This review aims to explore the current research on pyrazole derivatives, highlight the efficacy and mechanisms of action of pyrazole as an antibacterial agent, which will be beneficial for medicinal chemists.

Keywords: Antimicrobial, E. Coli, Pyrazole, S. Aureus, Streptococcus pneumonia.

View PDF