PERMEATION THROUGH NANOCHANNELS : A NOVEL SYSTEM FOR THE CHARACTERIZATION OF BIOLOGICAL CHANNELS
Published: 2008
Author(s) Name: Chinmay Khare, Tivadar Mach, Helge Weingart and Mathias Winterhalter
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Abstract
Nanotechnology is expected to be one of the future key technologies. One approach to realize nano-objects
is by self-assembly and involves an understanding of interaction on a molecular level. Numerous examples
are found in nature as self-organization on a nanometer scale is a fundamental building principle of life. Here
we discuss recent advances for characterization of natural nano channels using a microfluidic setup for highthroughput
and parallelized processing, making biological channels accessible for true engineering applications.
As an example we focus on the permeation of antibiotics through specific channels, a current problem in drugscreening
technology. For that we miniaturize a classical artificial bilayer set-up, automating the formation of
planar membranes to host channels and combining this with microfluidics.
Keywords: Nanotechnology, Nanochannels, Biological Channels
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