Impact of Angiogenic Signalling Mechanism in Cancer Progression: Interference with Herbal Drugs

Abstract

Angiogenesis is a complex process that is involved in the pathogenesis of many diseases, including cancer and ischemic disorders. The intricate process of angiogenesis plays a pivotal role in various physiological and pathological conditions, making it a subject of profound interest in medical research. Traditional Chinese medicine (TCM) has evolved over the past few decades to explore the multifaceted aspects of the process, exploring its mechanisms, regulators, and implications in health and disease. In this review, we focus on the anti-angiogenic properties of herbal drugs in the treatment of cancer, with a focus on their anti-angiogenesis effects. In addition, we discuss the potential of herbs in preventing or inhibiting angiogenesis, thereby disrupting the blood supply crucial for tumor growth and metastasis. Furthermore, we highlight the role of vascular endothelial growth factor (VEGF) signalling pathways in the regulation of tumor growth. The integration of traditional wisdom with modern scientific methodologies can enhance our understanding of the mechanisms underlying the anticancer and anti-Angiogenic effects of herbal medicines. As our understanding deepens, herbal drugs may emerge as valuable components of comprehensive and personalized cancer treatment strategies. The combination of traditional and modern medicine may offer an individualized approach to cancer treatment, addressing the heterogeneity of tumors and patient responses.

Keywords: Angiogenesis, Angiogenic factors, Cancer, Herbal drugs.

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