In Vitro Antiglycation Activity of Cympobogon Citratus and Cynodon Dactylon

Abstract

Plant is an important source of medicine and plays a key role in human health. Medicinal plants having both antiglycation and antioxidant activity can be of good therapeutic value in reducing complications of diabetes and slowing down aging process. Advanced Glycation End product (AGE’S) formation is due to non- enzymatic glycation and oxidative stress, which has been demonstrated in the pathogenesis of diabetic complication and aging processes. In this study we have investigated the antiglycation effect of Cynodon dactylon and Cympobogon citratus plants which are being used in the treatment of diabetes mellitus. Results indicated that the concentration of the Cympobogon citratus extract increases and the absorbance decreases from 0.027 ± 0.011 and reaches minimum 0.012 ± 0.0011 at 390 µg/ml. The same trend is observed with Cynodon dactylon extract too which reaches its minimum of 0.006 ± 0.0028 at concentration of 390 µg/ml from maximum absorbance of 0.024 ± 0.006. Antiglycation activity of Cympobogan citratus is more as compared to Cynodan dactylon. The result also show that precent inhibition of glycation reaction by Cympobogon citratus is lower than Cynodon dactylon.

Keywords: Advanced Glycation End products (AGEs), Antiglycation, Cympobogon citratus, Cynodon dactylon, Diabetes mellitus.

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