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Molecular Properties of Natural Bioactive Compounds Confined in Zea Mays and Its Application

Journal of Scientific and Technical Research

Volume 7 Issue 2

Published: 2017
Author(s) Name: A. K. Mishra | Author(s) Affiliation: Dept. of Physics, Dr. Shakuntala Misra National Rehabilitation Univ., Lucknow, Uttar Pradesh, India.
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Abstract

Despite substantial progress in recent years, ample therapeutic challenges remain in the treatment of the various diseases. Addressing these challenges requires recognition of pristine classes of drugs and development of non invasive and lucrative methods to select the most appropriate therapeutic option for the disease. The present study discusses the drug property of a natural bioactive compounds contained in Zea mays and aims to establish the active principles of bioactivity The present study investigates the renoprotective properties of a natural non-protein compound pelargonidin-3-glucoside confined in Zea mays that inhibits Angiotensin-I Converting Enzyme. The compounds to be explored as better inhibitors with respect to binding of various drugs like Perindopril available in market and the interactions responsible for the bioactivity of the compound have been discussed using computational methods.

Keywords: ACE-II (Angiotensin-II converting enzyme), Bioactivity, LUMO pelargonidin-3-glucoside.

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