Recent Developments in N,S,O Donor Schiff Base Molecules as Anti-Cancer Therapeutics

Abstract

Biological importance in many fields, including anti-cancer activity, and advances in inorganic chemistry with biological applications have heightened the scope of interest in Schiff bases and their complexes due to the combination of an aldehyde with an amine are useful chelate to produce coordination spheres with mixed N/O donors. The discovery of Schiff base and its complexes’ antitumor activity against various tumor cell lines captures the interest of researchers seeking to develop new anti-cancer drugs with no side effects. O-vanillin is a very useful aldehyde for preparing Schiff base ligands. It is found in the extract of vanilla. It is readily soluble in water. This aldehyde can combine with several different types of amine to form Schiff base which can form complexes with high stability with the majority of metals, which is caused by the azomethine group’s nitrogen (N) in addition to two oxygen (O) atoms from the hydroxyl and methoxy groups. Apoptosis is a natural death process of damaged, senescent, or abnormal cells that stops cancer development. It is reduced or blocked in cancer cells and can be triggered again by anti-cancer drugs. Therefore, in anti-cancer research, inducing cancer cell apoptosis is a favourable goal to be achieved by a new molecule blocked in cancer cells and can be triggered again by anti-cancer drugs. This review focuses on recent advances in N,S,O donor Schiff base molecules for Anti-cancer applications.

Keywords: Apoptosis, Inhibition, Malignant, Therapeutic

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