Signaling Pathways Associated with Cancer Development and Metastasis
Published: 2022
Author(s) Name: Annesha Das, Rishi Anand, Vikas Sharma, Arun Kumar, Anshul Singh and Sandeep Kumar |
Author(s) Affiliation: School of Pharmacy, Sharda University, Greater Noida, Uttar Pradesh, India
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Abstract
Cancer is one of the leading causes of mortality and morbidity worldwide. From decades and decades cancer has been the most undefeated diseases all over the world, despite of clinical research and trials. Cancer term also refers to proliferation of cells. At the time of cancer development, there is a imbalance between tumor suppresser genes and tumor oncogenes. Among the type of cancers, lung and breast cancer are the most common type of cancer worldwide. It further leads for abnormal cell cycle and results in tumor formation. This whole process involves a series of pathways like, Wnt-Beta Catenin pathway, TNF pathway, MAPK pathway, NF-kB pathway, Arf/p53 pathway, intrinsic and extrinsic pathways of apoptosis. This exhaustive review note throughs a lime light on different pathways for the development and progression of cancer. Scientists working in related field may find this article useful. The role of different enzymes and biomolecules in cancer development has been elaborated in the manuscript.
Keywords: Abnormal cell cycle, Biomolecules, Cancer, Different pathways, Proliferation.
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