Solid State Green Synthesis and Properties on Paracetamol-Phenobarbital Binary Drug System
Published: 2018
Author(s) Name: H. Shekhar and Raj Laxmi |
Author(s) Affiliation: Dept. of Chemistry., V.K.S. University, Ara, Bihar, India.
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Abstract
Molecular interaction between nonsteroidal antiinflammatory
drug (NSAID)/analgesic/antipyretic drug and
antiepileptic drug was studied taking views effectiveness
and enhanced pharmaceutical properties. The objective of
the present communication is to highlight thermodynamic
and interfacial investigation of paracetamol (PCM) and
phenobarbital (PB) binary drugs. The value of integral
excess Gibbs energy gE in the PCM-PB system shows the
positive deviation from ideal behaviour. It refers stronger
association between the molecules of same drug during
formation of binary mix. The negative value of Gibbs free
energy of mixing (?GM) suggests the mixing of parent drug
in eutectic and non eutectic binary drug is spontaneous. The
interfacial property of binary drugs has been determined by
the help of interfacial energy (s) and roughness parameter
(a). The size of critical nucleus of binary drug at different
undercoolings was in nano size is substantiated its great
future for pharmaceutical industries.
Keywords: Binary drug, Critical radius, Excess and mixing thermodynamic function, Interfacial energy.
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