This study examined the impact of Vipassana mindfulness meditation (MM) and the underlying mechanisms through which it exerts a positive effect on dimensions of subjective well-being. One hundred eighty healthy professionals completed the pre-intervention and postintervention online surveys during the COVID-19 pandemic. The experimental group (n=90) attended their first 10 days Vipassana MM course in India, while the control group (n=90) got acceptance but could not attend the same. 2 x 2 mixed design MANCOVA and serial multiple mediation models (PROCESS macro) were used for statistical analysis. Group x time interaction effect indicated that Vipassana MM led to significant enhancement in subjective wellbeing (SWB), trait emotional intelligence (EI), presence of meaning (PM) and mindfulness vis-à-vis the control group.