This paper investigates factors that predict the work-life balance of employees in NGOs in Ethiopia using quantitative research approach and explanatory research design. Data was collected from 163 managerial and professional employees using a structured questionnaire and responses were analyzed. Results revealed low levels of perceived Work Overload, Family Role Overload, and Work-family Balance and moderate levels of perceived Work-life Balance Policies, and high levels of perceived Workplace Support. Work Overload, Family Role Overload, Social Support, and Work-life Balance Policies predicted the Work-life Balance. To improve the situation, in addition to the existing work-life balance policies, the management should introduce need-based family friendly workplace policies such as f l exi bl e work i ng arrangement s, leave arrangements and child care benefits.