This study has taken job satisfaction and well-being as work-related attitudes and explored the interaction effect of job satisfaction with organizational culture on organizational performance. Responses have been collected from diverse people across India from different industries who have worked in organizations and are wellversed in work-related attitudes. The study utilized the partial least square structural equation modeling (PLSSEM) technique to analyze the data. The study established the link between workplace spirituality and work-related attitude and its effect on organizat ional perf ormance. The resul t s clearly show the importance of the group and rational cultural preference over hierarchical and entrepreneurial organizational culture dimensions. The study has uniquely examined the organizational culture’s elements and their direct and indirect effect on organizational performance.